Background. Conventional flexible bronchoscopy has limited sensitivity in the diagnosis of peripheral lung lesions and is dependent\non lesion size. However, advancement of CT imaging offers multiplanar reconstruction facilitating enhanced preprocedure\nplanning. This study aims to report efficacy and safety while considering the impact of patient selection and multiplanar CT\nplanning. Method. Prospective case series of patients with peripheral lung lesions suspected of having lung cancer who underwent\nflexible bronchoscopy (forceps biopsy and lavage). Endobronchial lesions were excluded. Patients with negative results underwent\nCT-guided transthoracic needle aspiration, surgical biopsy, or clinical-radiological surveillance to establish the final diagnosis.\nResults. 226 patients were analysed. The diagnostic yield of bronchoscopy was 80.1% (181/226) with a sensitivity of 84.2% and\nspecificity of 100%. In patients with a positive CT-Bronchus sign, the diagnostic yield was 82.4% compared to 72.8% with negative\nCT-Bronchus sign (
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